Clarithromycin Plus CCB Raises Acute Kidney Injury Risk Renal and Urology News Concurrent use of a calcium-channel blockers (CCB) and clarithromycin is associated with an increased risk of hospitalization for acute kidney injury (AKI), new findings show. CCBs are metabolized by the cytochrome P450 3A4 (CYP3A4) enzyme, and levels ... |