University of Rochester Newsroom | Alzheimer's Gene Causes Brain's Blood Vessels to Leak, Die University of Rochester Newsroom The left photo shows destructive proteins (green) lining blood vessels in living brain tissue of mice with the human ApoE4 gene; after the drug cyclosporine A is added, the harmful proteins are nearly gone (right). A well-known genetic risk factor for ... NIH-funded research provides new clues on how ApoE4 affects Alzheimer's risk Alzheimer's gene opens floodgate in brain |