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BioNews TexasBOLERO-3: Everolimus Might Help Patients Overcome Trastuzumab ResistanceOncLiveAdding the mTOR inhibitor everolimus to conventional therapy slowed the progression of trastuzumab-resistant advanced breast cancer, and in the process, provide…
BioNews TexasMD Anderson Researchers Reveal That Genetic Alterations Affect Everolimus …BioNews TexasEverolimus Benefit in breast cancer Breast cancer is one of the most common cancers in terms of incidence throughout the United States and the world….
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Genetic alterations affect everolimus benefit in breast cancer
The Oncology Report CHICAGO – The benefit of everolimus in hormone receptor–positive, HER2-negative advanced breast cancer appears to be greater for women who have little or no genetic alteration in this cancer’s most commonly altered molecular signaling pathways, … |
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Astellas Announces FDA Approval of ASTAGRAF XL™ (tacrolimus extended …
PR Newswire (press release) The two primary, randomized, comparative phase 3 clinical studies to support FDA approval enrolled 1,093 patients (545 on tacrolimus extended-release) in the U.S., Europe, Canada, South America, Australia and South Africa. Astellas was granted … |
Study demonstrates effectiveness of everolimus for TSC patientsNews-Medical.netA drug originally developed to prevent the rejection of transplanted organs has now been shown to dramatically reduce seizures in patients with tuberous sclerosis complex (T…
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Prednisolone Reduces Mild, Moderate Bell’s Palsy Sequelae
Medscape May 24, 2012 — The anti-inflammatory drug prednisolone significantly reduces mild and moderate aftereffects of Bell’s palsy, but does not have the same benefit for patients with more severe sequelae, according to a study published in the May issue of … |
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Federal Circuit Finds Wyeth Restenosis Claims Invalid As Not Enabled
Mondaq News Alerts (registration) As summarized by the Federal Circuit, “[t]he defendants market stent products that elute everolimus and zotarolimus, two drugs that have the same macrocyclic ring as sirolimus but different substituents at the C–42 position.” Wyeth urged a claim … |
Interspecies Transplant Works – Without Immunosuppressive DrugsScience 2.0Using their new method of xenotransplantation, the islets survived without immunosuppressive drugs. For people with hard-to-control type 1 diabetes, a transplant of insulin-produ…
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BOLERO 3: Everolimus may overcome trastuzumab resistance in HER2-positive …
The Oncology Report CHICAGO – The mTOR inhibitor everolimus appears to be effective at overcoming trastuzumab resistance in patients with advanced HER2-positive breast cancer, based on findings from the BOLERO-3 trial. The 572 patients studied all had locally advanced … |