Heart Failure Drug May Not Ease Symptoms in Some WebMD The medication, called spironolactone (Aldactone), failed to improve symptoms or quality of life among 422 patients with diastolic heart failure -- a form of the disease that affects about half of all people with heart failure. The drug did, however ... Mixed Results For Spironolactone In Heart Failure With Preserved Ejection ... Spironolactone disappoints in preserved-EF heart failure: Aldo-DHF in print Long-Term Use of Medication Does Not Improve Symptoms for Heart Failure ... |