Intracellular signaling prevents effective blockade of oncogenic gp130 mutants ... 7thSpace Interactive (press release) As a consequence, Stat3 activation through CAgp130 cannot be inhibited by neutralizing gp130 antibodies but through overexpression of a dominant-negative Stat3 mutant. Conclusion: CAgp130 and WTgp130 differ significantly with respect to glycosylation, ... |
