2 Minute Medicine | Spironolactone not reduce primary outcome, did reduce hospitalizations for ... Science Codex Looking at the components of the primary outcome separately, only hospitalizations, specifically for heart failure, had a significantly lower incidence for those taking spironolactone compared to placebo, with 206 patients (12.0 percent) in the ... Heart Failure Drug Might Help Reduce Hospitalizations Spironolactone not beneficial in heart failure with preserved ejection ... Troubled NHLBI TOPCAT Trial Disappoints |